I. Innate Defenses Overview
A. Non-specific Barrier Immunity – First Line of Defense
1. Surface (physical) Barriers – intact skin, hair
a. specialized membranes – mucus
b. specialized structures
2. Antimicrobial substances – sweat, oil, saliva, stomach acid, lysozyme, enzymes
3. Normal flora - competitors, inhibitors
4. Species Immunity
Worksheet on Normal Flora
B. Nonspecific Cellular Defenses – Second Line of defense
1. Cellular Components -
a. RBC's - 5 mill/cc = 99%
b. WBC's - 5-9,000/cc
i. PMN's-neutrophils - 55-60%
ii. Lymphocytes - B and T's - 30-35%
iii. Monocytes - phagocytes - 5-8%
iv. Eosinophils - 2-4%
v. Basophils - 0-1%
c. Thrombocytes - platelets - 250 - 400,000/cc
2. Phagocytosis – Monocytes, neutrophils, eosinophils
3. Opsonisation by complement
4. APC – Antigen Presenting Cell – digests and displays the invader’s antigens
a. signs - pain, redness, swelling, temperature, pus
b. purpose - bathe in serum with abs, bring in phagocytes, make changes to denature foreign proteins, wall off invader
C. Cell to Cell Communication
D. Chemical Mediators
1. Describe factors related to nonspecific immunity.
2. Categorize the specific chemical and mechanical barriers in the body.
3. Describe inflammation - its components and purpose.
4. Describe the blood components and their major functions and components of the lymphatic system and their functions.
5. Evaluate the significance of abnormal blood counts.
Go to this website for a great over view
Select the fourth box down “Anatomy of a Splinter” Click on oooouuuuch This covers the initial immune response in pictures. Click on the videos for action and rather crazy sounds added by the author.
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College | Kern Community College
District | Janet Fulks
1801 Panorama Dr. - Bakersfield, CA 93305 - (661)395-4381
Date last updated 10/31/2011