The Innate Immune Response

I. Innate Defenses Overview

          A. Non-specific Barrier Immunity – First Line of Defense

1. Surface (physical) Barriers – intact skin, hair


             a. specialized membranes – mucus


b. specialized structures

2.  Antimicrobial substances – sweat, oil, saliva, stomach acid, lysozyme, enzymes

3.  Normal flora - competitors, inhibitors


4.  Species Immunity

Worksheet on Normal Flora

    B. Nonspecific Cellular Defenses – Second Line of defense

              1.  Cellular Components -


                                         a. RBC's - 5 mill/cc = 99%


                                         b. WBC's - 5-9,000/cc



                                                              i. PMN's-neutrophils - 55-60%

bands <1%

ii.  Lymphocytes - B and T's - 30-35%


  iii.  Monocytes - phagocytes - 5-8%


  iv.  Eosinophils - 2-4%


   v.   Basophils - 0-1%

                                            c. Thrombocytes - platelets - 250 - 400,000/cc


      2.  Phagocytosis – Monocytes, neutrophils, eosinophils

    3. Opsonisation by complement

                        4.  APC – Antigen Presenting Cell – digests and displays the invader’s antigens

                        5. Inflammation

a. signs - pain, redness, swelling, temperature, pus         

b. purpose - bathe in serum with abs, bring in phagocytes, make changes to denature foreign proteins, wall off invader























C. Cell to Cell Communication

                      D. Chemical Mediators

                        1. Interferons

                        2. Cytokines

                        3. Complement




Chapter 15 Nonspecific Lines of Defense - Innate Immune System

1. Describe factors related to nonspecific immunity.

2. Categorize the specific chemical and mechanical barriers in the body.

3. Describe inflammation - its components and purpose.

4. Describe the blood components and their major functions and components of the lymphatic system and their functions.

5. Evaluate the significance of abnormal blood counts.


Immunology Websites

Go to this website for a great over view

Select the fourth box down “Anatomy of a Splinter” Click on oooouuuuch  This covers the initial immune response in pictures. Click on the videos for action and rather crazy sounds added by the author.

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Bakersfield College | Kern Community College District | Janet Fulks
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Date last updated 10/31/2011
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